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Tuesday 21 November 2006

High-dose ziprasidone-induced acute dystonia.

By: Rosenfield PJ, Girgis RR, Gil R.

Prog Neuropsychopharmacol Biol Psychiatry 2006 Nov 21; [Epub ahead of print]

There are few clinical data describing the relative risks of extrapyramidal symptoms (EPS) at higher doses of ziprasidone (i.e., greater than 160 mg/day) when compared to lower doses. We report on a patient who displayed no EPS with ziprasidone 160 mg/day for several months, but did display marked, acute dystonic reactions on ziprasidone 240 mg/day. The observations from the present case indicate that high-dose, ziprasidone-induced acute dystonia may occur even if no such side effects have been experienced at doses up to and including 160 mg/day.

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