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Monday 26 November 2007

Efficacy of antipsychotics to reverse phencyclidine-induced social interaction deficits in female rats-A preliminary investigation.

By: Snigdha S, Neill JC.

Behav Brain Res 2007 Oct;(): [Epub ahead of print]

Sub-chronic phencyclidine (PCP) treatment mimics certain aspects of schizophrenia symptomology in rats. However, there is a marked lack of attempts to model negative symptomology such as social behaviour deficits in female rats. This study was conducted to assess whether sub-chronic PCP treatment produces social interaction deficits in female rats and to ascertain if these deficits can be reversed by either typical (haloperidol) or atypical (clozapine and ziprasidone) antipsychotics.

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